Maxence VINCENT - Research Page

CNRS - LCB - Marseille (FRANCE)

We study how bacteria survive the oxidative attacks from the immune system and biocides

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Marseille
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▶ Research
Redox
Repair Systems
▶ Teaching

For L3 Wuhan students: The 2025 version of the Molecular Microbiology course will be available online at the end of November.

Lectures

Bacterial Stress Responses

L3 Wuhan

Nov/Dec 2025
Journal Club / Lecture

List of Papers Discussed in this Course

AMU MIF Master 1 students

Feb 2025
Lecture

Antibiotic-induced Mutagenesis

AMU MIF Master 1 students

Jan 2024
Lecture

Single-cell Era in Microbiology

AMU MIF Master 2 students

Oct 2023
Lecture

Non-genetic Variability in Microbiology

AMU MIF Master 2 students

Sep 2022
Lectures

Replication - Repair - Regulation

L3 Wuhan

Nov/Dec 2022, 2023, 2024
▶ Publications
  1. Loiseau, L.; De Visch, N.; Vergnes, A.; Armengaud, J.; Vincent, M. S.; Ezraty, B.. Repair of oxidized methionine residues in the chaperone Spy maintains periplasmic proteostasis under chlorite stress in Escherichia coli. PLoS Biol 2025,23 (9), e3003411
  2. Bongiovanni, T. R.; Latario, C. J.; Le Cras, Y.; Trus, E.; Robitaille, S.; Swartz, K.; Schmidtke, D.; Vincent, M.; Kosta, A.; Orth, J.; Stengel, F.; Pellarin, R.; Rocha, E. P. C.; Ross, B. D.; Durand, E. Assembly of a Unique Membrane Complex in Type VI Secretion Systems of Bacteroidota. Nat Commun 2024, 15 (1), 429.
  3. Vincent, M. S.; Vergnes, A.; Ezraty, B. Chlorate Contamination in Commercial Growth Media as a Source of Phenotypic Heterogeneity within Bacterial Populations. Microbiology Spectrum 2023, 11 (2), e04991-22.
  4. Vincent, M. S.; Ezraty, B. Methionine Oxidation in Bacteria: A Reversible Post-Translational Modification. Molecular Microbiology 2023, 119 (2), 143–150.
  5. Vincent, M. S.; Hervada, C. C.; Sebban-Kreuzer, C.; Guenno, H. L.; Chabalier, M.; Kosta, A.; Guerlesquin, F.; Mignot, T.; McBride, M. J.; Cascales, E.; Doan, T. Dynamic Proton-Dependent Motors Power Type IX Secretion and Gliding Motility in Flavobacterium. PLOS Biology 2022, 20 (3), e3001443.
  6. Vincent, M. S.; Uphoff, S. Cellular Heterogeneity in DNA Alkylation Repair Increases Population Genetic Plasticity. Nucleic Acids Research 2021, 49 (21), 12320–12331.
  7. Vincent, M. S.; Uphoff, S. Bacterial Phenotypic Heterogeneity in DNA Repair and Mutagenesis. Biochemical Society Transactions 2020, 48 (2), 451–462.
  8. Vincent, M. S.; Chabalier, M.; Cascales, E. A Conserved Motif of Porphyromonas Type IX Secretion Effectors C-Terminal Secretion Signal Specifies Interactions with the PorKLMN Core Complex. bioRxiv November 29, 2018, p 483123.
  9. Leone, P.; Roche, J.; Vincent, M. S.; Tran, Q. H.; Desmyter, A.; Cascales, E.; Kellenberger, C.; Cambillau, C.; Roussel, A.; Type IX Secretion System PorM and Gliding Machinery GldM Form Arches Spanning the Periplasmic Space. Nat Commun 2018, 9 (1), 429.
  10. Vincent, M. S.; Canestrari, M. J.; Leone, P.; Stathopulos, J.; Ize, B.; Zoued, A.; Cambillau, C.; Kellenberger, C.; Roussel, A.; Cascales, E. Characterization of the Porphyromonas Gingivalis Type IX Secretion Trans-Envelope PorKLMNP Core Complex. J. Biol. Chem. 2017, 292 (8), 3252–3261.
  11. Vincent, M. S.; Cascales, E. Probing Inner Membrane Protein Topology by Proteolysis. In Bacterial Protein Secretion Systems: Methods and Protocols; Journet, L., Cascales, E., Eds.; Springer: New York, NY, 2017; pp 97–103.
  12. Vincent, M. S.; Durand, E.; Cascales, E. The PorX Response Regulator of the Porphyromonas Gingivalis PorXY Two-Component System Does Not Directly Regulate the Type IX Secretion Genes but Binds the PorL Subunit. Front. Cell. Infect. Microbiol. 2016, 6.
▶ Resources

MMDE: This app allows users to visualize data from mother machine experiments, especially CSV outputs from the BACMMAN plugin (FIJI).

Lab Protocol: Chip Making and Experimental Setup (microfluidics, videomicroscopy, analyses)

Lab Protocol: Bioreactor Assembly and Manipulation

Lab Protocol: Media and Buffers

Lab Protocol: Cloning and Genetics (E. coli and Salmo)

Lab Protocol: Biochemistry and Enzymatic Assays

Lab Protocol: Templates for LabNotebook and LabMeetings

▶ Fundings
ANR
CNRS Innovation
CENTURI
IM2B
MSCA PF
AMU
CNRS
LCB
IMM
HFSP
EMBO
FRM
▶ Crew
MV
MJ
MB
JB
▶ Contact

Interested in our research or joining the team? Feel free to reach out!

Maxence's email: mvincent@imm.cnrs.fr

Laboratoire de Chimie Bactérienne (LCB), CNRS, 31 Chemin Joseph Aiguier, 13009 Marseille, France

Our lab is just 10 minutes from downtown Marseille: France’s second city, founded by the Greeks 600 years BC and only 15 minutes from the Calanques, a paradise for climbing, hiking, and sea adventures.

The perfect spot to enjoy city life or recharge on the trails between plasmid minipreps!

La calanque de Morgiou
Morgiou
Vieux-Port
Vieux-Port
Notre Dame
Notre Dame de la Garde